TF-dependent signaling in colon epithelial cells induces KC levels. (A) KC production in colon homogenates of wild-type and TFlow mice after 7 d DSS treatment. (B) TF and PAR-2 expression in colon sections of ulcerative colitis patients. (C) KC production after ex vivo stimulation of wild-type and TFlow colon section with FVIIa for 24 h. Data are means ± SEM of three independent experiments. *P < 0.05.