Figure 3

Ablation of AEBP1 influence on lipid and energy metabolism in LDLR^−/− mice. (A) Plasma cholesterol levels of AEBP1^+/+/LDLR^−/− and AEBP1^−/−/LDLR^−/− mice after 13 wks of atherogenic diet feeding. Error bars represent SEM, *P ≤ 0.05 (n = 4 males, P = 0.44; n = 5 females, P = 0.034). Plasma triglycerides levels of AEBP1^+/+/LDLR^−/− and AEBP1^−/−/LDLR^−/− mice after 13 wks of atherogenic diet feeding. Error bars represent SEM (n = 5 males, P = 0.26; n = 5 females, P = 0.28). (B) Measurement of body weight of AEBP1^+/+/LDLR^−/− and AEBP1^−/−/LDLR^−/− mice fed an atherogenic diet. Three-week-old mice were fed an atherogenic diet for 13 wks. Body weight was measured weekly. (C) Food intake was measured weekly and normalized to body weight. Total energy intake per group in a cage was calculated as the mean value per 100 g body weight. The data points represent the mean values of 13 weekly measurements of total energy intake. Error bars represent SEM, *P ≤ 0.05 (n = 5 males, P = 0.377; n = 5 females, P = 0.006). (D) Feed efficiency was calculated with the weekly measurements of mean values of weight gain and food consumption. The data points represent the mean values of 13 weekly measurements of feed efficiency. Error bars represent SEM, *P ≤ 0.05 (n = 5 males, P = 0.004; n = 5 females, P = 0.374).