Figure 4

Histology and liver collagen accumulation in wild-type and CB1^−/− mice after fibrosis induction. (A) wild-type (WT) control; (B) WT + TAA/EtOH treatment, 18 wks; (C) CB1^−/− control; (D) CB1^−/− + TAA/EtOH treatment, 18 wks. Fibrotic septa are clearly visible on tissues of WT alcohol-treated mice (red color), whereas only minor fibrosis is found in CB1^−/− mice following TAA/EtOH treatment. Shown are representative images (magnification 10x). Fibrosis stages after 18 wks of TAA/EtOH (E) and relative HYP (F), µg/g of wet liver (mean ± SD; **P < 0.005).