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Table 1 Demographic and clinical characteristics of the four developmental-age groups.

From: The Influence of Developmental Age on the Early Transcriptomic Response of Children with Septic Shock

 

Neonate

Infant

Toddler

School-age

Number of patients

17

62

54

47

Age (years)

0.1 (0.0–0.1)

1.0 (0.7–1.5)

3.0 (2.4–4.4)

8.6 (7.3–9.3)

Males/females (n)

13/4

37/25

29/25

30/17

Deaths [n (%)]

8 (47)a

8 (13)

6 (11)

7 (15)

PRISM score

24 (14–35)b

16 (8–22)

15 (10–19)

11 (10–17)

Maximum number of organ failurec

3 (3–4)d

2 (2–3)

2 (2–3)

2 (2–3)

Days to death from presentation

2 (1.5–5)

7 (5–14.5)

2 (1–9)

2 (1–10)

White blood cell count × 103/mm3

3.5 (2.3–9.9)b

16.1 (7.2–22.8)

13.4 (7.1–17.6)

13.2 (7.8–18.2)

Neutrophil count × 103/mm3

0.9 (0.4–4.9)b

11.4 (4.7–18.5)

8.1 (3.9–14.2)

9.4 (3.4–13.8)

% Neutrophils

45 (30–55)b

70 (58–79)

73 (58–83)

77 (69–87)

Lymphocyte count × 103/mm3

1.3 (0.8–3.0)

2.3 (1.1–4.5)e

2.3 (0.9–3.8)

1.3 (0.6–2.3)

% Lymphocytes

46 (34–59)b

19 (8–31)

18 (10–31)

11 (6–18)

Monocyte count × 103/mm3

0.2 (0.0–0.3)f

0.8 (0.4–1.5)

0.6 (0.3–1.4)

0.3 (0.1–0.9)

% Monocytes

6 (2–9)

6 (3–8)

7 (3–10)

4 (2–8)

Number with gram-positive bacteria (%)

8 (47)g

18 (29)

15 (28)

6 (13)

Number with gram-negative bacteria (%)

0 (0)h

18 (29)

17 (31)

11 (23)

Number with other organism (%)i

2 (12)

5 (8)

4 (7)

5 (11)

Number with negative cultures (%)

7 (41)

21 (34)

18 (33)

25 (53)

Number with bacteremia (%)

8 (47)

23 (37)

20 (37)

9 (19)

Number with comorbidities (%)

2 (12)d

25 (40)

26 (48)

23 (49)

  1. All data are median (interquartile range) unless otherwise noted.
  2. aP < 0.05 versus infant, toddler and school-age (χ2).
  3. bP < 0.05 versus infant, toddler and school-age (ANOVA on ranks).
  4. cRefers to maximal number of organ failures over the first 7 d of admission.
  5. dP < 0.05 versus toddler and school-age.
  6. eP < 0.05 versus school-age (ANOVA on ranks).
  7. fP < 0.05 versus infant and toddler (ANOVA on ranks).
  8. gP < 0.05 versus school-age (χ2).
  9. hP < 0.05 versus infant and toddler (χ2).
  10. iRefers to viral or fungal pathogens.