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Table 1 Representative gene expression profile in HoxD10transfectants compared with empty vector control (fold change) by cDNA microarray

From: Homeobox D10 Gene, a Candidate Tumor Suppressor, Is Downregulated through Promoter Hypermethylation and Associated with Gastric Carcinogenesis

Gene

  

Fold

 

symbol

Gene description

GenBank accession

change

Gene function

ADAM28

ADAM metallopeptidase domain 28

NM_014265

3.84

Ad,Pa

ALOX5

arachidonate 5-lipoxygenase

NM_000698

2.10

Ad,An,Ap,CC,M,P,ST

ANP32A

acidic (leucine-rich) nuclear phosphoprotein 32 family, member A

NM_006305

2.88

Ap,P

AQP3

aquaporin 3 (Gill blood group)

NM_004925

0.43

I,M,P

CALB1

calbindin 1, 28kDa

NM_004929

3.25

Ap,CC,M,ST

CX3CL1

chemokine (C-X3-C motif) ligand 1

NM_002996

3.50

Ad,An,Ap,M,P

CXCL9

chemokine (C-X-C motif) ligand 9

NM_002416

2.19

Ad,An,Ap,CC,I,M,P,ST

FLG

filaggrin

NM_002016

0.41

Ad,Ap,CC,I,M,P

GATA6

GATA binding protein 6

NM_005257

2.01

Ad,Ap,P

GZMB

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

NM_004131

0.48

Ad,Ap,I,P

HCLS1

hematopoietic cell-specific Lyn substrate 1

NM_005335

5.10

Ap,M,P,ST

GFBP3

insulin-like growth factor binding protein 3

NM_001013398

2.33

Ad,An,Ap,CC,I,M,P,ST

IL7R

interleukin 7 receptor

NM_002185

2.11

Ad,Ap,CC,I,P,ST

IL8

interleukin 8

NM_000584

2.29

Ad,An,Ap,CC,I,M,P,ST

KLK11

kallikrein-related peptidase 11

NM_144947

0.43

Ap,M,P

KRT18

keratin 18

NM_000224

0.36

Ad,An,Ap,CC,I,M,P,ST

KRT5

keratin 5

NM_000424

0.25

Ad,Ap,I,P

KRTT6A

keratin 6A

NM_005554

0.29

I,P

MME

membrane metallo-endopeptidase

NM_007289

0.43

Ad,An,Ap,CC,I,M,P,ST

NTS

neurotensin

NM_006183

0.25

Ad,An,Ap,CC,I,M,P,ST

PDGFRL

platelet-derived growth factor receptor-like

NM_006207

2.82

P,I

RAC2

Ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

NM_002872

0.16

Ad,Ap,CC,I,M,P,ST

SAA1

serum amyloid A1

NM_000331

2.07

Ad,An,Ap,I,M

TNF

tumor necrosis factor (TNF superfamily, member 2)

NM_000594

2.07

Ad,An,Ap,CC,I,M,P,ST

TUSC3

tumor suppressor candidate 3

NM_178234

0.41

Ap,CC,I

UPK1B

uroplakin 1B

NM_006952

0.40

ST

  1. aAd, adhesion; P proliferation; An, angiogenesis; Ap, apoptosis; CC, cell cycle; M, migration; ST, signal transduction; I, invasion.