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Table 8 SNPs reported to be associated with IgAD and selected autoimmune disorders.a

From: Selective IgA Deficiency in Autoimmune Diseases

   

IgAD

GD

SLE

T1D

CD

   

OR

 

OR

 

OR

 

OR

 

OR

 

Locus

Gene

SNP

(95% CI)

Pvalue

(95% CI)

P value

(95% CI)

P value

(95% CI)

P value

(95% CI)

P value

1p13

PTPN22

rs2476601

    

1.35 (1.24–1.47)

2.04 (1.81–2.29)

  

1q25.3

NMNAT2

rs2022013

    

0.85 (0.79–0.90)

    

1q31.2

RGS1

rs2816316

      

0.89 (0.84–0.95)

0.80 (0.76–0.84)

2q12.1

ILWRAP

rs917997

        

1.19 (1.14–1.25)

2q24

IFIH1

rs1990760

0.67 (0.59–0.76)

  

1.17 (—)

0.85 (0.81–0.90)

  

2q32.2

STAT4

rs7574865

    

1.57 (1.49–1.69)

    

2q33.2

CTLA4

3 SNPs

  

1.49 (1.34–1.66)

  

0.85 (0.78–0.92)

1.14 (1.09–1.19)

3p14.3

PXK

rs6445975

    

1.25 (1.16–1.35)

    

3p21

CCR1/CCR3

2 SNPs

        

1.30 (1.23–1.39)

3q25.33

IL21A

rsl 7810546

      

1.09 (1.04–1.14)

1.36 (1.29–1.44)

3q28

LPP

rsl 464510

        

1.29 (1.25–1.34)

4q27

IL2–IL21

2 SNPs

  

0.87 (0.79–0.95)

  

1.27 (1.15–1.39)

0.74 (0.70–0.78)

5p13

IL7R

rs6897932

      

0.89 (0.84–0.94)

  

6p21.32

HLA

Multi-SNPs

2.53(2.17–2.95)

4.6 (—)

2.36 (2.11–2.64)

6.85 (—)

6.23 (5.95–6.52)

6q21

ATG5

rs573775

    

1.19 (1.12–1.27)

    

6q23.3

TNFAIP3

3 SNPs

    

1.17(1.10–1.25)

0.90 (0.86–0.95)

1.23 (1.17–1.28)

6q25.3

TAGAP

rs1738074

      

0.92 (0.88–0.96)

1.16 (1.12–1.21)

7p21.3

ICA1

rs10156091

    

1.32(1.19–1.47)

    

7q32

IRF5

rs2070197

    

1.88 (1.78–1.95)

    

8p23.1

BLK

rs2736340

    

1.35 (1.27–1.43)

    

8q12

LYN

2 SNPs

    

0.77 (0.70–0.84)

    

10p11

NRP1

rs2666236

      

1.21 (1.11–1.31)

  

11p15.5

KIAA1542

rs4963128

    

0.78 (0.71–0.85)

    

11p15.5

INS

187111341

      

1.25(1.15–1.35)

  

12q13.2

ERBB3

rs2292239

      

1.28(1.21–1.35)

  

12q24

SH2B3

rs653178

      

1.28 (1.22–1.35)

1.20 (1.15–1.24)

1óp11.2

ITGAM

3 SNPs

    

1.62 (1.47–1.78)

    

16p13.13

CLEC16A

3 SNPs

0.64 (0.54–0.77)

  

1.16 (—)

0.81 (0.77–0.86)

0.86 (0.82–0.91)

18p11.21

PTPN2

2 SNPs

      

1.30 (1.22–1.40)

1.17 (1.12–1.23)

18q22.2

CD226

rs763361

      

1.16(1.10–1.22)

  

22q11.21

UBE2L3

2 SNPs

    

1.22 (1.14–1.32)

  

1.13(1.08–1.19)

22q13.2

SCUBEI

rs2071725

    

0.78 (0.72–0.86)

    
  1. aColor-code from dark red to green represents the strong and weak association, respectively:
  2. 5E-32~lower
  3. 5E-26~5E-32
  4. 5E-20~5E-26
  5. 5E-14~5E-20
  6. 5E-08~5E-14
  7. 5E-08~higher .