Figure 7

Proposed mechanism by which PARylation enhances HMGB1-associated inhibition of efferocytosis. PARylation increases the ability of HMGB1 to inhibit efferocytosis by binding more efficiently to PS on apoptotic cells and to RAGE on macrophages, thereby diminishing association of the apoptotic cell with the macrophage by interfering with binding between RAGE and PS.