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Figure 3 | Molecular Medicine

Figure 3

From: Effect of Cigarette Smoke Exposure and Structural Modifications on the α-1 Antitrypsin Interaction with Caspases

Figure 3

Requirement of the RCL for the A1AT inhibition of capsase-3 activity. (A) Western blot of recombinant human MM-A1AT, ZZ-A1AT or RCL-null A1AT produced in E. coli. Representative of n = 2. (B) Kinetic activity of recombinant human caspase-3 (∼1 U/µL) against a fluorescently labeled substrate in the presence of purified human recombinant MM-A1AT, ZZ-A1AT or RCL-null A1AT (45 µg/mL) (mean + SEM; n = 3–5); ns, nonsignificant statistical difference.

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Molecular Medicine

ISSN: 1528-3658