Table 1 Subjects’ demographic and clinical characteristics.a
No clinical diagnosis of COPD nonsmoker | No clinical diagnosis of COPD smoker | COPD nonsmoker | COPD smoker | P | |
|---|---|---|---|---|---|
(n = 8) | (n = 8) | (n = 5) | (n = 8) | ||
Age, years | 53.5 ± 6.6 | 39.5 ± 7.7 | 63.8 ± 3.4 | 52.25 ± 3.6 | 0.09 |
Race, white % | 87.5 | 62.5 | 100 | 75 | 0.37 |
Cigarette smoking, pack-years | 7.3 ± 4.1 | 15.0 ± 5.6 | 74 ± 12.4 | 47.5 ± 15.4 | 0.0008 |
Current smokers, % | 0 | 100 | 0 | 100 | <0.0001 |
Cachexia, % | 0 | 0 | 20 | 37.5 | 0.0768 |
Asthma, % | 12.5 | 12.5 | 20 | 0 | 0.68 |
FEV1, % predicted | NA | NA | 50.6 ± 11.986 | 44.88 ± 6.337 | 0.6507 |
FEV1/FVC, % | NA | NA | 53.2 ± 8.941 | 58.5 ± 5.039 | 0.586 |
Emphysema diagnosed radiographically, % | NA | NA | 80 | 50 | 0.56 |
Oral or inhaled corticosteroid use, % | 25 | 12.5 | 100 | 75 | 0.003 |
Other medications (β-agonist, | |||||
anticholinergic, methylxantine), % | 12.5 | 12.5 | 100 | 100 | <0.0001 |