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Figure 1 | Molecular Medicine

Figure 1

From: Glycine N-Methyltransferase Deficiency Affects Niemann-Pick Type C2 Protein Stability and Regulates Hepatic Cholesterol Homeostasis

Figure 1

Gnmt-/- mice developed steatohepatitis and hyperlipidemia. (A) Hematoxylin and eosin staining of liver tissues from WT and Gnmt-/- mice at 11 wks and 9 months of age. Original magnification 200×. Inset: Higher magnification image of microvesicular intracytoplasmic lipid droplet. (B) Filipin and Nile red staining of liver tissues from 11-wk-old WT and Gnmt-/- mice. Arrow, free cholesterol; arrowhead, hydrophobic lipids. Scale bar, 20 µm. Hepatic (C) and serum cholesterol (D), free cholesterol and LDL levels in 11-wk-old WT and Gnmt-/- mice (n = 6 mice per group). *P < 0.05; **P < 0.01. ■, WT; □, Gnmt-/-.

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Molecular Medicine

ISSN: 1528-3658