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Figure 5 | Molecular Medicine

Figure 5

From: Serum from Patients Undergoing Remote Ischemic Preconditioning Protects Cultured Human Intestinal Cells from Hypoxia-Induced Damage: Involvement of Matrixmetalloproteinase-2 and -9

Figure 5

Addition of MMP-2 and MMP-9 does not influence phosphorylation of p42/44, phosphorylation of Akt or activity of caspase-3/7. (A) Effects of MMP-2 and MMP-9 on phosphorylation of p42/44 and Akt. Hypoxia reduces the phosphorylation of p42/44 and Akt compared with normoxic conditions. Addition of MMP-2 and MMP-9 has no additional effects. (B) Regulation of caspase-3/7 activity by MMP-2 and MMP-9. Compared to normoxic conditions, activities of effector caspases 3 and 7 are increased by hypoxia. Addition of MMP-2 and MMP-9 has no additional effects on caspase activity. Numbers in the columns display the numbers of independently performed experiments. Columns show the mean ± SEM. *P < 0.05, ***P < 0.001, one-way ANOVA, Bonferroni posttest. rdu, relative densitometric units; rfu, relative fluorescence units.

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Molecular Medicine

ISSN: 1528-3658