Figure 3

Extended immunophenotype of proliferative and resting CLL fractions. Surface markers were analyzed by flow cytometry in CXCR4^dimCD5^bright (X) and CXCR4^brightCD5^dim (G) fractions. All surface molecules are depicted but CCR7 and CTLA4 were greater in CXCR4^dimCD5^bright fractions, in terms of percent positive cells (A) or mean fluorescence intensity (B) or both. CCR7 and CTLA4 are higher in the CXCR4^brightCD5^dim fraction. *P < 0.01 and ^§P < 0.05 (paired Student t test).