Figure 3

p110β protein expression is increased in FXS patient LCLs compared with healthy control. The increase is similar to what can be observed in synaptic fractions (SNS) from Fmr1 KO mice (as shown previously in (3,23)). Quantification of p110β-specific signal normalized to tubulin in LCLs is shown in lower panel (n= 4, *P= 0.002, paired t test). Quantification of other class 1A catalytic PI3K subunits p110α and p110δ showed no significant differences (Figure S2). a.u., Arbitrary units.; norm., normalized; □, Ctr; ■, FXS.