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Figure 8 | Molecular Medicine

Figure 8

From: Milk Fat Globule-Epidermal Growth Factor 8 Is Decreased in Intestinal Epithelium of Ulcerative Colitis Patients and Thereby Causes Increased Apoptosis and Impaired Wound Healing

Figure 8

Assessment of apoptotic-related proteins in MFG-E8 knockdown IEC lines. The mRNA level of the antiapoptotic factor BCL-2 in Caco-2 cells (A) and proapoptotic factor BAX in Caco-2 (B) and HT-29 cells (C) with LV-M or LV-C transduction is shown. (D) Western blot analysis of cleaved caspase-3, BCL-2 and BAX protein level with LV-M or LV-C transduction in HT-29 and Caco-2 cells. (E) Western blot analysis of cleaved caspase-3, BCL-2 and BAX protein levels in IECs incubated with rhMFG-E8 at different concentrations for 24 h.

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Molecular Medicine

ISSN: 1528-3658