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Figure 4 | Molecular Medicine

Figure 4

From: Benefits of Recombinant Adeno-Associated Virus (rAAV)-Mediated Insulinlike Growth Factor I (IGF-I) Overexpression for the Long-Term Reconstruction of Human Osteoarthritic Cartilage by Modulation of the IGF-I Axis

Figure 4

Expression of IGFBPs and IGF-IR in rAAV-transduced human articular cartilage. Primary human normal and OA cartilage explant cultures were transduced with either rAAV-hIGF-I or the control rAAV-lacZ vector, as described in Figure 3, and processed after 90 d to detect the expression of IGFBP3 (A), IGFBP4 (B), IGFBP5 (C) and IGF-IR (D). Magnification 20×. All are views of the middle zone.

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Molecular Medicine

ISSN: 1528-3658