Skip to main content
Figure 5 | Molecular Medicine

Figure 5

From: Benefits of Recombinant Adeno-Associated Virus (rAAV)-Mediated Insulinlike Growth Factor I (IGF-I) Overexpression for the Long-Term Reconstruction of Human Osteoarthritic Cartilage by Modulation of the IGF-I Axis

Figure 5

Expression of phospho-ERK-1/2, phospho-Akt, phospho-Elk-1 and SOX9 in rAAV-transduced human articular cartilage. Primary human normal and OA cartilage explant cultures were transduced with either rAAV-hIGF-I or the control rAAV-lacZ vector, as described in Figure 3, and processed after 90 d to detect the expression of phospho-ERK-1/2 (A), phospho-Akt (B), phospho-Elk-1 (C) and SOX9 (D). Magnification 20×. All are views of the middle zone.

Back to article page

Molecular Medicine

ISSN: 1528-3658