Table 1 IGF-I production in rAAV-transduced chondrocytes in vitro and in situ.

Monolayer cultures (ng/10⁷ viable cells/24 h)

5

3.40 (0.08)

29.30 (0.81)^a

2.60 (0.05)

18.87 (0.92)^a

10

0.08 (0.01)

27.03 (0.70)^a

0.06 (0.01)

18.89 (0.68)^a

20

n.d.

21.84 (0.53)^a

n.d.

16.68 (0.64)^a

Alginate cultures (ng/10⁷ viable cells/24 h)

5

2.70 (0.03)

25.02 (0.22)^a

3.75 (0.02)

24.73 (0.09)^a

26

n.d.

24.60 (0.16)^a

n.d.

22.79 (0.13)^a

Explant cultures (pg/mg dry weight/24 h)

5

0.42 (0.06)

16.97 (1.22)^a

0.27 (0.03)

14.14 (1.02)^a

12

0.12 (0.04)

13.61 (1.16)^a

0.10 (0.05)

12.71 (1.01)^a

30

0.09 (0.02)

26.24 (2.31)^a

0.16 (0.03)

29.23 (1.58)^a

60

0.14 (0.03)

26.82 (1.98)^a

0.11 (0.02)

28.91 (2.06)^a

90

0.11 (0.03)

32.41 (1.84)^a

0.09 (0.03)

37.20 (2.12)^a