Table 1 Summary of redox characterized cysteine modifications with resulting inflammatory readouts and schematic molecular structure of HMGB1 (different cysteine redox states characterized by LC-MS/MS within HMGB1 and their relation to cytokine Induction and NF-κB nuclear translocation in cultured macrophages).
Molecule (representative spectra) | Schematic molecular overview | Cytokine inducing capacity and NF-κB nuclear translocation |
|---|---|---|
A (Trace A-1, A-2, A-3) |
| Yes |
B (Trace B-1, B-2, B-3) |
| No |
C (Trace A-1,C-1, C-2) |
| No |
D (Trace B-1, A-2, A-3) |
| No |
E (Trace A-2, A-3) |
| No |
F (Trace A-1, C-1) |
| No |
