Skip to main content
Figure 6 | Molecular Medicine

Figure 6

From: Toll-Like Receptor 4 Engagement Inhibits Adenosine 5′-Monophosphate-Activated Protein Kinase Activation through a High Mobility Group Box 1 Protein-Dependent Mechanism

Figure 6

Lack of AMPK activation, despite increase in AMP-to-ATP ratio, in the lungs of LPS-treated mice. The amounts of AMP, ATP (A) and phosphorylation of AMPK and ACC (B-D) were determined in lung homogenates obtained from mice given saline or LPS (1 mg/kg) intratracheally 24 h previously. Representative Western blots (B) and quantitative data (C and D) are shown (mean ± SD, n = 6, *P < 0.05 compared with control mice). (E) Representative Western blots show the amounts of LKB1 and of HMGB1 in whole lung homogenates after immunoprecipitation of LKB1 from lung homogenates of control and LPS-treated mice (three mice per group).

Back to article page

Molecular Medicine

ISSN: 1528-3658