Figure 2
From: Dichotomy between RIP1- and RIP3-Mediated Necroptosis in Tumor Necrosis Factor-α-Induced Shock
Genetic deficiency of RIP3 protects from TNFα-mediated shock in the presence and absence of caspase inhibition. Wild-type mice (open circles) and RIP3-deficient mice (black squares, n = 8 per group) were treated with mouse TNFα in the absence (A) or presence (B) of zVAD. Survival is presented as a Kaplan-Meyer plot. Genetic RIP3-deficiency protects from both TNFα-mediated shock (P < 0.001) and hyperacute TNFα/zVAD-mediated shock (P < 0.01), respectively.