Table 3 Univariate analysis in the entire cohort as well as in grades II/III and grade IV separately.

Histological grade (II versus III versus IV)

<0.0001

0.0327

—

Age (>35 versus ≤35 years)

0.0253

0.6588

0.1082

Sex (1: male, 2: female)

0.7155

0.5600

0.7978

Surgical excision (0: partial, 1: almost complete)

0.1191

0.0660

0.0741

Radiotherapy (0: absence, 1: presence)

0.3824

0.4535

0.0243

Chemotherapy (0: absence, 1: presence)

0.5346

a

0.1288

SOCS-3 expression (30% versus ≥30%)

0.0044

0.8808

0.0833

CXCR2 expression (negative versus positive)

0.0071

0.0568

0.3617

IL-8 expression (<5% versus ≥5%)

0.0005

0.2985

0.1470

p-STAT-3 expression (<8% versus ≥8%)

0.9407

0.5477

0.0430