Figure 3

IRAK-M^−/− mice demonstrate less tissue injury during Klebsiella pneumonia. WT (closed symbols) and IRAK-M-deficient (IRAK-M^−/−) (open symbols) mice were infected intranasally with 1 × 10⁴ CFU K. pneumoniae and euthanized at 6, 24 and 48 h after induction of pneumonia. ASAT (A), ALAT (B) and LDH (C) in plasma were determined. Dotted lines represent mean values of healthy mice (n = 4). Data are expressed as mean ± SEM; n = 7–9/group; *P < 0.05 and **P < 0.01 as compared with WT mice. (D) Survival was observed in WT (closed symbols) and IRAK-M^−/− (open symbols) mice after intranasal infection with 1 × 10⁴ CFU K. pneumoniae. n = 10/group. P value indicates the difference between groups.