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Figure 1 | Molecular Medicine

Figure 1

From: Aldehyde Dehydrogenase-2 Deficiency Aggravates Cardiac Dysfunction Elicited by Endoplasmic Reticulum Stress Induction

Figure 1

Effect of tunicamycin (TN) challenge on ER stress in WT mice and ALDH2 KO mice. Protein levels in myocardium from WT mice and ALDH2 knockout mice with or without TN exposure were determined. (A) ALDH2. (B) GRP78. (C) p-eIF2α. (D) CHOP (E) Apoptosis was detected using TUNEL assay. (F) Data depicted that ALDH2 KO significantly promoted apoptosis after a TN challenge, compared with WT mice. All values for given protein expression were normalized to that of GAPDH. The data (presented as percentages of control) are means ± SEM of three separate experiments. *p < 0.05 versus WT group; #p < 0.05 versus ALDH2 KO-TN group.

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Molecular Medicine

ISSN: 1528-3658