Table 2 Statistically significant differences in (A) CD25 and (B) CD86 expression between different CLL subgroups with distinct clonotypic BcRs after stimulation of TLRs and NOD2 with their respective ligands.^a

A. CD25

   TLR1/2

#1 versus #8

30.7 versus 82.8

0.050

#4 versus non-#4/16

57.85 versus 7.9

0.007

UM versus #8

52.4 versus 82.8

0.050

   TLR2/6

#4 versus non-#4/16

35.05 versus 10.6

0.033

#16 versus non-#4/16

47 versus 10.6

0.004

M versus #16

22.1 versus 47

0.021

   TLR7

M versus UM

8.4 versus 50.1

0.001

#4 versus #1

11 versus 46.8

0.026

UM versus #8

50.1 versus 75.6

0.028

   TLR9

#4 versus non-#4/16

61.9 versus 32.8

0.022

   NOD2

#4 versus non-#4/16

27.8 versus 14.7

0.019

B. CD86

   TLR1/2

#4 versus #1

51 versus 11

0.034

#4 versus non-#4/16

51 versus 9.8

0.003

#16 versus non-#4/16

55.5 versus 9.8

0.038

   TLR2/6

#4 versus #1

41.4 versus 6.3

0.049

#4 versus non-#4/16

41.4 versus 15.3

0.022

#16 versus non-#4/16

41.1 versus 15.3

0.002

M versus #16

21.3 versus 41.1

0.004

   TLR7

UM versus #8

4.2 versus 18.3

0.034

   TLR9

M versus UM

40.4 versus 8.2

0.001

#4 versus #1

56.8 versus 4.3

0.001

#4 versus #16

56.8 versus 24.9

0.031

#1 versus #8

4.3 versus 26.8

0.048

   NOD2

#4 versus #1

31.5 versus 2.8

0.001

#4 versus non-#4/16

31.5 versus 16.2

0.019

M versus #4

15.2 versus 31.5

0.021