Figure 6
Effects of MSCs on the basal and depolarization-evoked release of (3H)d-aspartate in synaptosomes purified from the spinal cord of control saline-injected SOD1 and saline- or MSC-injected SOD1/G93A mice. Animals were intravenously injected with 106 MSCs or saline at d 90 and sacrificed at d 125. Synaptosomes were labeled with the radioactive tracer and exposed in superfusion to 15 mmol/L (A) or 25 mmol/L (B) KCl. Results are expressed as fractional rate × 100. Six MSC-treated and six saline-injected SOD1/G93A mice were used. Saline-injected SOD1 mice were used as controls. Means ± SEM of six experiments run in triplicate are presented. *p < 0.05 at least (ANOVA plus Bonferroni).