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Figure 5 | Molecular Medicine

Figure 5

From: Pharmacological Rescue of the Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Detected by Use of a Novel Fluorescence Platform

Figure 5

Correctors rescue F508del-CFTR FAP function. SPQ fluorescence traces showing iodide efflux in response to 10 µmol/L forskolin stimulation are shown. (A) N-terminus and EL4 FAP-CFTR WT reporters show channel function overlapping with untagged CFTR WT. Stably expressing FAP-F508del-CFTR (B) or F508del-CFTR EL4-FAP (C) cells were treated with either vehicle (DMSO) or a combination of correctors (C4 + C18 for 24 h). Iodide efflux was stimulated with forskolin and a potentiator (300 nmol/L P2).

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Molecular Medicine

ISSN: 1528-3658