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Figure 10 | Molecular Medicine

Figure 10

From: Pigment Epithelium-Derived Factor (PEDF) Peptide Eye Drops Reduce Inflammation, Cell Death and Vascular Leakage in Diabetic Retinopathy in Ins2Akita Mice

Figure 10

Reduction in inflammatory cytokine levels in the diabetic vitreous after treatment with P60 and P78 peptide eye drops. The histograms represent Affymetrix Luminex bead measurements of cytokine levels in the vitreous. An increase in 8/20 inflammatory cytokines was detected in the diabetic condition compared with the normal controls. Both of the PEDF derivatives reduced vitreous levels of these cytokines, but maximal effect was seen after P78 treatment. Only P78 reduced TNFa (p = 0.003) and IL2 (p = 0.006) levels (n = 5). All values are means ± SD.

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Molecular Medicine

ISSN: 1528-3658