Figure 5
From: MGMT Inhibition Restores ERα Functional Sensitivity to Antiestrogen Therapy
Benzylguanine inhibits tamoxifen-resistant breast tumor growth and sensitizes resistant breast cancer cells to antiestrogen therapy. Mammary tumors were treated with a single agent (TAM/ICI/BG) or with combination therapy (BG + TAM/ICI). Treatment effect was measured by tumor volume and weight. BG either alone or in combination with TAM/ICI significantly decreased breast tumor growth.