Figure 1

IOP changes in the different groups. Temporal changes in IOP in response to episcleral vein ligation in experimental eyes (filled symbols) and fellow eyes (open symbols) of mice from the 3-wk (A) and 10-wk (B) cohorts. IOP from untreated control mice (squares) and from mice treated before the initial episcleral vein ligation with RHP (circles) are shown. Although not indicated in the graphs for clarity, IOP levels in the experimental eyes were significantly greater at all time points than levels measured at corresponding times in their fellow eyes, and significantly greater than their respective baselines at all times. Moreover, there were no significant differences in the extent of IOP elevation in the glaucoma eyes from the untreated and RHP-treated groups, nor significant differences in IOP levels between these groups in their respective fellow eyes. Baseline IOP (shown at time = 0) also did not differ between eyes or groups. Baseline IOP values and mean IOP values over the 24-h-to-3-wk and 24-h-to-10-wk periods of study in the 3-wk and 10-wk cohorts, respectively, with the N for each group (in parentheses), are provided in tabular form (C), wherein *P < 0.05 versus baseline in the same eye.