Figure 2
TH2 pattern in WT, TLR2, TLR4 and MyD88 KO animals after UUO. UUO led to increased levels of IL-4 (A) and IFN-γ (B) mRNA in WT mice when compared to control animals. Renal GATA3:TBX21 ratio (C) in TLR2, TLR4, and MyD88 KO mice. The ratio of WT mice subjected to UUO was considered 1. Type 1 arginase (D), GATA-3 (E), TSLP (F), Fizz-1 (G), TBX21 (H), TNFα (I), iNOS (J), IL-6 (K), CD68 (L) and MCP1 (M) mRNA expression in kidneys in in WT, TLR2, TLR4 and MyD88 KO animals 7 d after UUO. qPCR was normalized to HPRT, and the mean of the WT control mice was considered 1. *p < 0.05, **p < 0.01.