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Figure 2 | Molecular Medicine

Figure 2

From: CSE1L, a Novel Microvesicle Membrane Protein, Mediates Ras-Triggered Microvesicle Generation and Metastasis of Tumor Cells

Figure 2

CSE1L mediates microvesicle biogenesis induced by v-H-ras. (A) Representative micrographs show that CSE1L knockdown inhibited v-H-Ras-induced microvesicle biogenesis. (B) Immunofluorescence shows CSE1L and MMP-2 staining in microvesicles in the cytoplasm (arrowhead) and the base of invadopodia (arrow) of B16-Ras cells. (C) Representative images show CSE1L overexpression stimulates microvesicle generation in B16-CSE1L cells. (D) Representative micrograph of B16-CSE1L cells treated with DMSO or PD98059 in medium without FBS for 12 h.

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Molecular Medicine

ISSN: 1528-3658