Figure 3

Humoral and T-cell-mediated responses showing significant changes from baseline over the 24-wk study period, in the context of MVC intensification and immunization. Changes from baseline in: (A) anti-tetanus antibody titers; (B) anti-MenC antibody titers; and (C) anti-CTB antibody titers. Change from baseline in IFN-γ production to stimulation with: (D) HIV-1 Gag₂₀; and (E) TTox. (F) Change from baseline in proliferative response to stimulation with TTox. Mean changes from baseline estimated by mixed model analysis are plotted with bars above and below representing 95% confidence interval. Significance from baseline is shown by error bars that do not bisect the x axis, and is marked with *. Relevant immunizations are indicated by vertical dashed lines. All immunizations were administered at the time point indicated, after blood was drawn for immunological assessments. Ab, antibody.