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Figure 2 | Molecular Medicine

Figure 2

From: Glucocorticoid Receptor and Molecular Chaperones in the Pathogenesis of Adrenal Incidentalomas: Potential Role of Reduced Sensitivity to Glucocorticoids

Figure 2

(A) Normal adrenal cortex displayed positive focal immunostaining for glucocorticoid receptor (GR) by using an antibody that recognizes α and β isoforms of the receptor (anti-GRβα/β) in the zona reticularis (zr). (B) β Isoform of GR is expressed predominantly in the zona glomerulosa (zg) of normal adrenal cortex. (C) Tumorous (at) and peritumorous (pt) tissue stained with anti-GRα/β. Both tissues show immunoreactivity. (D) Immunoreactivity for GRβ is seen in the tumor (at) and in adjacent peritumorous tissue (pt). Focal and weak staining with anti-GRα/β (E) and with anti-GRβ (F) are demonstrated in adenomatous tissue. Cellular localization of GR is nuclear and/or cytoplasmic. Magnifications are presented in the lower right-hand corner of each photograph.

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Molecular Medicine

ISSN: 1528-3658