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Figure 4 | Molecular Medicine

Figure 4

From: Glucocorticoid Receptor and Molecular Chaperones in the Pathogenesis of Adrenal Incidentalomas: Potential Role of Reduced Sensitivity to Glucocorticoids

Figure 4

Representative Western blot for GR. (A) The MCF-7 cells and human lymphocytes (Ly) were used as positive controls. Monoclonal anti-GR antibody, which recognizes the α and β transcriptional isoforms of GR, reveals the presence of bands of about 100 kDa; however, the dominant 53- to 56-kDa receptor isoform that corresponds to GR-D is detected in normal adrenal cortex (AC) and periadenomatous (PT) tissue. In the majority of tumor samples (T), GR-D is the only isoform that can be seen. (B) GR-D expression was similar in normal adrenal cortex, peritumorous and tumorous tissues.

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Molecular Medicine

ISSN: 1528-3658