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Table 2 Frequencies of GR and ACTHR polymorphisms in patients and control subjects.

From: Glucocorticoid Receptor and Molecular Chaperones in the Pathogenesis of Adrenal Incidentalomas: Potential Role of Reduced Sensitivity to Glucocorticoids

Polymorphisms

Patients

Controls

OR (95% CI)

p

n

112

100

  

BclI (TGA → TCA)

    

GG

46 (41.1)

66 (66.0)

bl]Reference

 

GC

55 (49.1)

30 (30.0)

2.2 (1.3–4.0)

0.005

CC

11 (9.8)

4 (4.0)

2.6 (0.8–8.4)

0.110

Carriers of allele C

66 (58.9)

34 (34.0)

2.9 (1.7–5.1)

<0.001

N363S (ATT → GTT)

    

AA

104 (92.9)

95 (95.0)

bl]Reference

 

AG

8 (7.1)

5 (5.0)

1.48 (0.4 – 4.6)

0.509

ER22/23EK (GAGAGG → GAAAAG)

    

GG

109 (97.3)

99 (99.0)

bl]Reference

 

AA

3 (2.7)

1 (1.0)

2.7 (0.3 – 26.8)

0.385

Exon 9βA3669G

    

AA

68 (60.7)

83 (83.0)

bl]Reference

 

AG

41 (36.6)

17 (17.0)

2.8 (1.4–5.3)

0.002

GG

3 (2.7)

0 (0.0)

3.7 (0.4 – 87.8)

0.217

Carriers of allele G

44 (39.3)

17 (17.0)

3.0 (1.6–5.7)

0.001

ACTHR gene promoter (CTC→CCC)

    

TT

97 (86.6)

88 (88.0)

bl]Reference

 

TC

14 (12.5)

12 (12.0)

1.1 (0.5–2.5)

0.783

CC

1 (0.9)

0 (0.0)

1.8 (0.1–51.0)

0.627

Carriers of allele C

15 (13.4)

12 (12.0)

1.1 (0.5–2.5)

0.783

  1. Underlined bases indicate the transition.