Table 3 Clinical characteristics of patients carrying glucocorticoid receptor polymorphisms that are associated with increased risk for adrenal tumor.
BclI alleles | 9β alleles | |||||
|---|---|---|---|---|---|---|
C (n = 66) | G (n = 101) | p | A (n = 109) | G (n = 44) | p | |
BMI (kg/m2) | 27.1 ± 4.1 | 27.9 ± 4.5 | 0.366 | 28.1 ± 4.5 | 26.4 ± 4.1 | 0.042 |
Waist girth (cm) | 88.1 ± 12.3 | 92.0 ± 12.8 | 0.135 | 91.8 ± 12.9 | 87.3 ± 12.4 | 0.082 |
Systolic blood pressure (mmHg) | 146.1 ± 39.4 | 146.5 ± 29.4 | 0.950 | 151.4 ± 39.5 | 139.5 ± 28.8 | 0.092 |
Diastolic blood pressure (mmHg) | 90.2 ± 20.4 | 86.7 ± 14.4 | 0.327 | 91.0 ± 19.5 | 85.8 ± 15.9 | 0.147 |
Largest tumor diameter (mm) | 40.6 ± 18.1 | 31.1 ± 10.6 | 0.002 | 36.2 ± 17.0 | 37.9 ± 16.7 | 0.607 |
Glucose (mmol/L) | 5.4 ± 2.0 | 5.5 ± 2.1 | 0.785 | 5.7 ± 2.5 | 4.8 ± 0.7 | 0.031 |
Total cholesterol (mmol/L) | 5.7 ± 1.5 | 6.0 ± 1.5 | 0.239 | 5.8 ± 1.5 | 5.8 ± 1.6 | 0.893 |
Triglycerides (mmol/L) | 1.7 ± 0.7 | 1.8 ± 1.0 | 0.637 | 1.8 ± 0.8 | 1.7 ± 0.9 | 0.450 |
ACTH (pg/mL) | 21.2 ± 24.9 | 23.3 ± 30.2 | 0.692 | 25.8 ± 32.3 | 16.6 ± 14.4 | 0.082 |
Cortisol Basal (nmol/L) | 419.3 ± 166.2 | 413.6 ± 169.5 | 0.862 | 385.8 ± 156.7 | 449.1 ± 177.4 | 0.099 |
Post-Dex (nmol/L) | 80.7 ± 76.8 | 60.8 ± 48.1 | 0.129 | 61.0 ± 52.8 | 90.2 ± 81.6 | 0.025 |