Table 4 Relationship between glucocorticoid receptor gene polymorphisms and sensitivity to glucocorticoids in patients with adrenal tumors.
Concurrent presence of C allele of BclI and G allele of 9β polymorphisms | |||
|---|---|---|---|
Carriers (n = 21) | Noncarriers (n = 91) | p | |
BMI (kg/m2) | 25.3 ± 3.7 | 28.1 ± 4.4 | 0.010 |
Waist girth (cm) | 84.0 ± 12.3 | 91.5 ± 12.7 | 0.020 |
Blood pressure (mmHg) | |||
Systolic | 136.8 ± 32.5 | 149.2 ± 36.6 | 0.159 |
Diastolic | 86.1 ± 17.3 | 89.7 ± 18.5 | 0.434 |
Largest tumor diameter (mm) | 41.7 ± 20.3 | 36.2 ± 15.7 | 0.177 |
Fasting glucose (mmol/L) | 4.7 ± 0.9 | 5.6 ± 2.2 | 0.095 |
Total cholesterol (mmol/L) | 5.7 ± 1.7 | 5.8 ± 1.5 | 0.839 |
Triglycerides (mmol/L) | 1.8 ± 0.8 | 1.8 ± 0.8 | 0.964 |
ACTH (pg/mL) | 14.8 ± 7.4 | 24.0 ± 29.5 | 0.148 |
Cortisol | |||
Basal (nmol/L) | 489.9 ± 187.5 | 399.3 ± 157.2 | 0.024 |
Post-Dex (nmol/L) | 124.5 ± 103.6 | 60.2 ± 48.7 | <0.001 |