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Figure 4 | Molecular Medicine

Figure 4

From: Chronic Lymphocytic Leukemia Cells in a Lymph Node Microenvironment Depict Molecular Signature Associated with an Aggressive Disease

Figure 4

Confirmation of expression of pSyk and p-P65 in lymphoid tissue of a TCL-1 transgenic mouse model and human patients using immunohistochemistry. Panel I: A representative immunohistochemistry of LN tissue from TCL-1 transgenic mouse. Lymphoid tissue were collected at wk 37 from the mouse and stained for B220 (A), CD5 (B), p-P65 (C), pSYK (D) and control antibody (E). Average of percent positive B220/CD5+ cells for pSYK and p-P65 from the transgenic mice (n = 3) is shown (F). Panel II: A representative immunohistochemistry of LN from CLL patient. LN tissue from CLL patient is stained with CD5 (A), CD19 (B), p-P65 (C), p-SYK (D) and control antibody (E). Average of percent positive CD19/CD5+ CLL cells for p-SYK and p-P65 from patient LNs (n = 3) is shown (F).

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Molecular Medicine

ISSN: 1528-3658