Chronic Lymphocytic Leukemia Cells in a Lymph Node Microenvironment Depict Molecular Signature Associated with an Aggressive Disease

Table 1 Enriched pathways observed by using gene set enrichment analysis.^a

	LN enriched	BM enriched	PB enriched
LN versus BM	Immune suppressive (Sasaki ATL Up), Cancer progression (Cancer Neoplastic Meta Up)	B-cell differentiation (Martinelli Ifns Differentiation, Haddad HSC CD7 Up)	No comparison made
LN versus PB	Immune suppressive (Sasaki ATL Up), Cancer progression (Cancer Neoplastic Meta Up), B-CLL poor prognosis (IgVH_3-21 Gene signature)	No comparison made	Immunity and inflammation (Passerini_Immune, Passerini Inflammation)
BM versus PB	No comparison made	B-cell differentiation (Martinelli Ifns Differentiation, Haddad Hsc Cd7 Up), Cell cycle and antiapoptosis (Yagi AML_Prognosis)	Cell cycle regulatory (Cell Cycle pathway, Ageing Brain Up, G1 To S Cell Cycle Reactome)

^aThe words in parentheses in this table are names of signatures, which pop up through GSEA analyses on the GSEA website. Each name indicates a specific gene set at the GSEA website.

ISSN: 1528-3658