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Figure 2 | Molecular Medicine

Figure 2

From: Effect of Recombinant α1-Antitrypsin Fc-Fused (AAT-Fc) Protein on the Inhibition of Inflammatory Cytokine Production and Streptozotocin-Induced Diabetes

Figure 2

Dose-dependent suppression of TNFα-induced IL-6 production in human PBMCs. (A) AAT-Fc inhibited TNFα-induced IL-6 production in a dose-dependent manner, and AAT-Fc used at a concentration of 13 nmol/L abolished IL-6 production completely. However, the same concentration of plasma-derived AAT has no effect on IL-6 induction. (B) Unlike the effects of AAT on TNFα-induced IL-6 production, both AAT-Fc and AAT failed to suppress LPS-induced IL-6 production. The mean ± SEM values of three independent experiments have been shown. **p < 0.01; ***p < 0.001 (n = 3 per group).

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Molecular Medicine

ISSN: 1528-3658