Table 1 Results of baseline quantitative sensory testing.
Variable | ARA 290* | Placebo | |||
|---|---|---|---|---|---|
Nerve fibers involved | Change | Number of patients (%) | Change | Number of patients (%) | |
Cold detection threshold | Aδ and C | Decrease | 7 (64) | Decrease | 9 (90) |
Warm detection threshold | Aδ and C | Decrease | 7 (64) | Decrease | 6 (60) |
Thermal sensory limen | Aδ and C | Decrease | 3 (27) | Decreased, increased | |
Paradoxical heat sensation | Aδ | Decrease | 1 (9) | — | 0 |
Cold pain threshold | Aδ and C | — | 0 | Increase | 1 (10) |
Heat pain threshold | C | Decrease, increase | Decrease, increase | ||
Mechanical detection threshold | Aβ | Decrease, increase | Decrease | 1 (10) | |
Mechanical pain threshold | Aβ | Decrease | 2 (18) | Decrease | 3 (30) |
Mechanical pain sensitivity | Aβ + C | Decrease | 1 (9) | Increase | 2 (20) |
Dynamic mechanical allodynia | Aβ | Increase | 1 (9) | Increase | 4 (40) |
Windup ratio | Aδ and C | — | 0 | Increase | 1 (10) |
Vibration detection threshold | Aβ | Decrease | 6 (55) | Decrease | 6 (60) |
Pressure pain threshold | Aδ and C | Increase | 2 (18) | Increase | 8 (80) |