Figure 2

Anxiety phenotype in Baiap3 KO mice. (A-F) Open field parameters. (A, B) The latency to reach the wall of the open field was significantly increased in Baiap3 KO mice of both sexes, whereas visits to the center (C, D) and stay in the periphery (E, F) revealed anxiety-like behavior only in females. Elevated plus-maze (G, H) and light-dark box (I, J) revealed no genotype-dependent differences in either sex. (K, L) As readout of unspecific novelty-related anxiety, a higher freezing response was found in male as well as female Baiap3 KO mice. Numbers tested: males, WT = 16–25, KO = 16–25; females, WT = 18–23, KO = 10–28. Mann-Whitney U test (A–D, I–L) and two-way ANOVA (E–H), including Bonferroni testing, were applied. Means ± SEM are presented.