Figure 5From: Activated Protein C Inhibits Proliferation and Tumor Necrosis Factor α-Stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial FibroblastsThe proposed mechanism of action of APC on RSFs, as shown in this study. RSF proliferation contributes to inflammation, which further promotes a cyclic perpetuation in RA. APC acts on signaling molecules that inhibit both RSF proliferation and inflammation.Back to article page