Skip to main content
Figure 4 | Molecular Medicine

Figure 4

From: Low-Dose T3 Replacement Restores Depressed Cardiac T3 Levels, Preserves Coronary Microvasculature and Attenuates Cardiac Dysfunction in Experimental Diabetes Mellitus

Figure 4

Diabetes leads to reexpression of fetal genes in adult cardiac tissue. (A) MHC isoform mRNA distribution shown as % of total MHC mRNAs as measured by qPCR. (B) Protein expression of β-MHC isoform and total MHC detected by Western blot. Expression represented as ratio of β-MHC to total MHC expression. (C) Cardiac protein expression of sarcoplasmic reticulum proteins detected by Western blot. (D) Quantitative summary of normalized protein expression. MHC, myosin heavy chain; SERCA2a, sarcoplasmic/endoplasmic reticulum calcium ATPase 2; PLB, phospholamban; p-PLB, phosphorylated phospholamban (site of phosphorylation); n = 4–8/group. *p < 0.05 versus control; †p < 0.05 versus STZ/N.

Back to article page

Molecular Medicine

ISSN: 1528-3658