Table 2 Differentially expressed proteins of HP isolates related to AAG compared with those of HP isolates related to GC.

HP proteins upregulated in AAG compared with GC

13

27557/9.68

gi | 238057731

tRNA pseudouridine synthase A

Cytoplasm/tRNA processing

HP P12

32/1.9e + 002/26

10.19

3.54E-03

n.d.^c

254

6644/10.96

gi | 1226703094

50S ribosomal protein L301

Cytoplasm/DNA translation/protein synthesis

Leptothrix cholodnii (strain ATCC51168/LMG8142/SP-6)

37/71/30

7.15

4.50E-03

(41)

206

n.i

5.85

0.049

168

22335/5.88

gi | 2507172

Probable peroxiredoxin or 26-kDa antigen or thioredoxin reductase

Cytoplasm/peroxidase activity/oxidoreductase

HP

82/0.0019/52

5.69

3.28E-04

(41–43)

244

22335/5.88

gi | 2507172

Probable peroxiredoxin or 26-kDa antigen or thioredoxin reductase

Cytoplasm/peroxidase activity/oxidoreductase

HP

75/0.0098/41

2.94

4.56E-03

(41–43)

33

61816/5.64

gi | 57014163

Urease β subunit

Secreted and cytosolic/pathogenesis/urea catabolic process/hydrolase

HP J99

102/2.1e−005/46

2.5

0.025

(24,42,43,53,62,75–77)

57

67136/4.99

gi | 226738136

Chaperone protein dnak or heat shock 70-kDa protein or HSP70

Cytoplasm/protein folding/stress response

HP (strain Shi470)

32/1.8e + 00 2/8

2.44

0.0115

(24,41)

34

61846/5.64

gi | 57014163

Urease β subunit

Secreted and cytosolic/pathogenesis/urea catabolic process/hydrolase

HP (strain PI2)

75/0.0099/37

2.36

5.45E-03

(24),41−43,53, 62,75−77)

39 161

58706/8.70

gi | 12493545

Catalase

Cytoplasm/hydrogen peroxide catabolic process/peroxidase/oxidoreductase

HP

106/8.1e−006/30

2.21

1.76E-03

(24,32,55,71,76,78)

n.i

2.2

8.87E-03

166

22335/5.88

gi | 2507172

Probable peroxiredoxin or 26-kDa antigen or thioredoxin reductase

Cytoplasm/peroxidase activity/oxidoreductase

HP

97/6e-005/48

2.15

3.10E-03

(41–43)

177

n.i

1.87

0.017

111

gi | 1706274

Bifunctional enzyme cysN/cysC

Cytoplasm/GTP catabolic process/sulfate assimilation

Mycobacterium tuberculosis

44/18/14

1.7

7.19E-03

n.d.^c

77

74074/5.11

gi | 12230111

Flagellar hook-associated protein 2

Secreted/bacterial flagellum/cell adhesion/flagellum assembly

HP J99

39/41/10

1.6

0.023

(79)

65

20180/5.84

gi | 1208432952

Peptidoglycan-associated lipoprotein

Outer membrane/bacterial envelope integrity

HP G27

41/9.1e +02/17

1.56

0.049

(59)

HP proteins downregulated in AAG compared with GC

35

58321/5.44

gi | 226704136

60-kDa chaperonin or GroEL

Cytoplasm/protein refolding/stress response/ATP binding

HP (strain P12)

68/0.057/23

−6.58

2.84E-03

(24),32,41–43, 53,59,62,75, 77,80)

248

22335/5.88

gi | 2507172

Probable peroxiredoxin or 26-kDa antigen or thioredoxin reductase

Cytoplasm/peroxidase activity/oxidoreductase

HP

44/13/34

−5.31

2.45E-03

(41–43)

37

n.i.

−4.96

9.54E-06

89

43734/5.17

gi | 2494256

Elongation factor Tu

Cytoplasm/GTP catabolic process/protein biosynthesis

HP

90/0.00035/33

−2.91

1.22E-05

(41,43,62,75)

141

n.i.

−2.6

6.38E-03

40

55280/5.29

gi | 226739893

ATP synthase subunit a or F-ATPase subunit a

nner membrane/plasma membrane ATP synthesis-hydrolysis coupled proton transport

HP

140/3.2e–009/32

−2.56

5.52E-05

(24,62,75,77)

42

53252/6.04

gi | 60392282

Flagellin A

Secreted/bacterial flagellum/flagellum motility and virulence

HP J99

88/0.00046/30

−2.45

0.025

(24,31,32,43,60)

165

n.i.

−1.99

0.034

92

n.i.

−1.99

1.66E-04

163

20584/5.20

gi | 254809526

Ribosome-recycling or releasing factor

Cytoplasm/protein biosynthesis

Rhodococcus opacus (strain B4)

32/2.2e +002/15

−1.93

0.036

(42)

135

n.i.

−1.86

6.50E-04

63

43734/5.17

gi | 2494256

Elongation factor Tu

Cytoplasm/GTP catabolic process/protein biosynthesis

HP

79/0.0037/33

−1.73

1.14E-04

(42,62,77)