Differential Proteomics of Helicobacter pylori Associated with Autoimmune Atrophic Gastritis

Table 3 Differentially expressed proteins of HP isolates related to AAG compared with those of HP isolates related to DU

Spot number^a	MW (Da)/pl	GenBank accession no.^b	Protein annotation	Localization/biological process/molecular function	Organism	Score/expect/Seq. coverage	Fold difference	p	Protein described previously (ref.)
Proteins upregulated by AAG compared with DU
57	67136/4.99	gi \| 226738136	Chaperone protein dnaK or HSP70	Cytoplasm/protein folding/stress response	HP (strain Shi470)	32/1.8e + 002/8	4.23	7.50E-04	(24,41)
168	22335/5.88	gi \| 2507172	Probable peroxiredoxin or 26-kDa antigen or thioredoxin reductase	Cytoplasm/peroxidase activity/oxidoreductase	HP	82/0.0019/52	2.15	0.0277	(41–43)
161		n.i.					2.09	0.0277
166	22335/5.88	P21762	Probable peroxiredoxin or 26-kDa antigen or thioredoxin reductase	Cytoplasm/peroxidase activity/oxidoreductase	HP	97/6e-005/48	1.69	0.0467	(41–43)
Proteins downregulated by AAG in comparison with DU 37		n.i.					−7.36	1.09E-04
117		n.i.					−2.3	0.039
76	19317/5.01	gi \| 2500043	norganic pyrophosphatase	Cytoplasm/phosphate-containing compound metabolic process/magnesium ion binding	HP	30/2.9E +002/12	−2.12	0.037	(13,24,62,77)
40	55280/5.29	gi \| 226739893	ATP synthase subunit a or F-ATPase subunit a	Membrane/ATP hydrolysis coupled proton transport/plasma membrane ATP synthesis coupled proton transport	HP	140/3.2e-009/32	−2.03	7.36E-03	(13,24,62,75)
42	53252/6.04	gi \| 60392282	Flagellin A	Secreted/bacterial flagellum/flagellum motility and virulence	HP (strain J99)	88/0.00046/30	-2.45	0.0897	(13,24,31,43)

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