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Figure 2 | Molecular Medicine

Figure 2

From: Underexpressed CNDP2 Participates in Gastric Cancer Growth Inhibition through Activating the MAPK Signaling Pathway

Figure 2

Effect of ectopic CNDP2 expression on tumor growth. (A) CNDP2 protein levels were assessed by Western blot in AGS cells. A marked increase in CNDP2 was evident in GV142-CNDP2 transfectants relative to the untreated control and GV142-NC transfectants, (B) Cell proliferation levels were measured by the CCK-8 assay. GV142-CNDP2 transfectants displayed significantly inhibited growth rates in AGS cells. (C) The upregulated expression of CNDP2 significantly inhibited the colony formation of AGS cells. (D) Ectopic CNDP2 expression decreased tumor growth in nude mice subcutaneously inoculated with AGS/GV142-CNDP2 compared with the untreated control and AGS/GV142-NC in vivo. (E) The tumor masses and tumor volume for three groups are compared; each histogram represents the mean ± SD of five mice. **p < 0.01 from the GV142-NC group.

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Molecular Medicine

ISSN: 1528-3658