Systemic Administration of a Cyclic Signal Transducer and Activator of Transcription 3 (STAT3) Decoy Oligonucleotide Inhibits Tumor Growth without Inducing Toxicological Effects

Table 2 Body weights and tissue weights at euthanasia.

Treatment	Body weight (g)	Liver (g)	Kidney (g)	Spleen (g)	Heart (g)	Thymus (g)	Lungs (g)	Brain (g)
Vehicle control	26.05 ± 1.685	1.12 ± 0.057	0.36 ± 0.036	0.118 ± 0.018	0.132 ± 0.015	0.073 ± 0.018	0.171 ± 0.011	0.454 ± 0.025
100 mg/kg STAT3 decoy	26.21 ± 2.106	1.14 ± 0.187	0.38 ± 0.032	0.120 ± 0.017	0.132 ± 0.015	0.082 ± 0.013	0.169 ± 0.012	0.463 ± 0.068
67 mg/kg STAT3 decoy	26.76 ± 4.073	1.24 ± 0.204	0.41 ± 0.076	0.123 ± 0.030	0.141 ± 0.018	0.080 ± 0.008	0.197 ± 0.019	0.470 ± 0.019
34 mg/kg STAT3 decoy	26.72 ± 1.669	1.06 ± 0.090	0.37 ± 0.037	0.107 ± 0.020	0.126 ± 0.025	0.066 ± 0.010	0.165 ± 0.007	0.460 ± 0.014

Data are means ± SD for each group. No significant differences were noted in body weight or any tissue (p ≥ 0.05, ANOVA or Kruskal-Wallis).

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