Systemic Administration of a Cyclic Signal Transducer and Activator of Transcription 3 (STAT3) Decoy Oligonucleotide Inhibits Tumor Growth without Inducing Toxicological Effects

Table 3 Evaluation of the statistical significance of clinical chemistry and hematology parameters.

Treatment	Variable	ANOVA	ttest	Kruskal-Wallis	Mann-Whitney
Cyclic STAT3 decoy (100 mg/kg)	Bicarbonate (mmol/L)	0.005	0.034	0.012	0.0472
	Anion Gap (mmol/L)	0.004	0.018	0.020	0.0157
Cyclic STAT3 decoy (67 mg/kg)	Mean corpuscular hemoglobin (pg)	0.028	0.0056	0.042	0.0189
	Urea nitrogen (mg/dL)	0.007	0.0305	0.020	0.0157
Cyclic STAT3 decoy (33 mg/kg)	Urea nitrogen (mg/dL)	0.005	0.041	0.012	0.0122
	Potassium (mmol/L)	0.005	0.018	0.016	0.0212
	Bicarbonate (mmol/L)	0.005	0.0113	0.012	0.031
	Anion gap (mmol/L)	0.004	0.0098	0.02	0.0216

Data are p values for ANOVA with pair-wise comparisons by two-sample t test and for Kruskal-Wallis with pair-wise comparisons using the Mann-Whitney test. Only the treatment groups are shown that demonstrated a significant difference by both ANOVA and Kruskal-Wallis and the individual group or groups that demonstrated a significant difference from the control saline-treated group by both t test and Mann-Whitney test.

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