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Figure 6 | Molecular Medicine

Figure 6

From: α7 Nicotinic Acetylcholine Receptor Signaling Inhibits Inflammasome Activation by Preventing Mitochondrial DNA Release

Figure 6

The mechanisms by which acetylcholine inhibits inflammasome activation. Extracellular ATP activates the NLRP3 inflammasome by provoking intracellular potassium efflux and mitochondrial DNA release into cytoplasm. Stimulation of ATP also results in rapid influx of acetylcholine into cytoplasm. There, acetylcholine prevents mitochondrial DNA release through α7 nAchR and subsequently inhibits the NLRP3 inflammasome activation.

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Molecular Medicine

ISSN: 1528-3658